Reevaluating the Prognostic Value of Histopathological Parameters in Soft Tissue Sarcoma of the Extremities

Various staging and grading systems aim to correlate morphological and clinical parameters with the prognosis of soft tissue sarcoma. However, the existing literature offers inconsistent findings. This retrospective cross-sectional study investigated the prognostic value of common histopathological parameters in predicting the survival of extremity soft tissue sarcoma patients. The study comprised 122 patients, and it evaluated parameters like tumour necrosis, mitotic count, tumour differentiation score, and tumour margin status. The survival outcomes were analysed concerning these histopathological variables. The 5-year survival rate was 48%, with a median survival of 88 months. Of the patients, 87.7% (n = 107) had tumour-free margins. Statistical analyses, including Kaplan-Meier Survival Analysis and Cox Proportional Hazard regression, revealed that none of these parameters exhibited significant prognostic value (p>0.05). This study found that none of the histopathological parameters examined demonstrate prognostic significance for long-term survival among soft tissue sarcoma patients over a 10-year follow-up period.