Honey: Food or Medicine?
Honey: Food or Medicine?
Vol. 8 No. 1 : 2013 (3-18)
Abstract
Honey is a natural substance produced by honeybees, Apis mellifera, from the nectar of blossomed flowers or exudates of trees and plants producing nectar honeys or honeydews, respectively. It is a supersaturated solution of sugars, enriched with proteins, minerals, vitamins, organic acids and polyphenols. Honey possesses numerous nutritional, healing and prophylactic properties attributed by the rich components found in honey. Some of the health beneficial properties include wound healing, antimicrobial, antioxidant and anti-inflammatory potential. This review relates the nutritional composition, antioxidant and therapeutical effects of honey with emphasis on Malaysian honeys.
Keywords :
anti-inflammatory,
Antioxidant,
health beneficial properties,
honey,
natural product,
Correspondance Address
Prof. Dr. Yasmin Anum Mohd Yusof, Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. Tel: +603-92897297 Fax: +603-26938037 Email: anum@medic.ukm.my/rahmatyasmin@yahoo.com
References
Abdelhafiz, A.T., Muhamad, J.A. 2008. Midcycle pericoital intravaginal bee honey and royal jelly for male factor infertility. Int J Gynaecol Obstet 101(2): 146-149.
Abdul-Ghani, A.S., Dabdoub, N., Muhammad, R., Abdul-Ghani, R., Qazzaz, M. 2008. Effect of Palestinian honey on spermatogenesis in rats. J Med Food 11(4): 799-802.
Abdul Kadir, E., Sulaiman, S.A., Yahya, N.K., Othman, N.H. 2013. Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Premilinary Study. Asian Pac J Cancer Prev 14(4):2249-2254.
Adebolu, T.T. 2005. Effect of natural honey on local isolates of diarrhea causing bacteria in South Western Nigeria. Afri J Biotech 4(10): 1172-1174.
Agbaje, E.O., Ogunsanya, T., Aiwerioba, O.I.R. 2006. Conventional use of honey as antibacterial agent. Annals Afri Med 5(2): 78-81.
Ajlouni, S., Sujirapinyokul, P. 2010. Hydroxymethylfurfuraldehyde and amylase contents in Australian honey. Food Chem 119: 1000-1005.
Al-Jabri, A.A., Al-Hosni, S.A., Nzeako, B.C., Al-Mahrooqi, Z.H., Nsanze, H. 2005. Antibacterial activityof Omani honey alone and in combination with gentamicin. Saudi Med J 26(5): 767-771.
Aljadi, A.M., Kamaruddin, M.Y., Jamal, A.M., Mohd Yassim, M.Y. 2000. Biochemical study on the efficacy of Malaysian honey on inflicted wounds: An aminal model. Medical Journal of Islamic Academy of Sciences 13(3): 125-132.
Allen, K.L., Molan, P.C., Reid, G.M. 1991. A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol 43(12): 817-822.
Allen, K.L., Hutchinson, G., Molan, P.C. 2000. The potential for using honey to treat wounds infected with MRSA and VRE: 10-13 September 2000: First World Healing Congress, Melbourne, Australia.
Al-Mamary, M., Al-Meeri, A., Al-Habori, M. 2002. Antioxidant activities and total phenolics of different types of honey. Nutr Res 22(9): 1041-1047.
Al-Qassemi, R.A.S., Robinson, R.K. 2003. Some special nutritional properties of honey-a brief review. Nutr Fd Sci 33(6): 254-260.
Al-Qur’an. Surah Al-Nahl (The bee) 16: 68-69. http://www.quran.com/16/68-69. (18 August 2012).
Al-Qur’an. Surah Muhammad 47: 15. http://www.quran.com/47/15. (18 August 2102).
Alvarez-Suarez, J.M., Tulipani, S., Romandini, S., Bertoli, E., Battino, M. 2010. Contribution of honey in nutrition and human health: a review. Mediterranean Journal of Nutrition and Metabolism 3: 15-23.
Al-Waili, N.S. 2003. Effects of daily consumption of honey solution on hematological indices and food levels of minerals and enzymes in normal individuals. J Med Food 6(2): 135-40.
Asiyah, H.A., Syazana, N.S., Hashida, N.H., Durriyyah Sharifah, H.A., Kamaruddin, M.Y. 2011. Effects of nicotine and Gelam honey on testis parameters and sperm qualities of juvenile rats. Sci Res Essays 6(26): 5471-5474.
Bang, L.M., Buntting, C., Molan, P.C. 2003. The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Complement Med 9(2): 267-73.
Bansal, V., Medhi, B., Pandhi, P. 2005. Honey a remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J (KUMJ) 3(3): 305-9.
Benefits of Honey. 2012. http://www.benefits-of-honey.com/health-benefits-of-honey.html. (11 September 2012).
Blair, S.E., Carter, D. 2005. The potential for honey in the management of wounds and infections. J Australian Infection Control 10(1): 24-31.
Bogdanov, S., Haldimann, M., Luginbuhl, W., Gallmann, P. 2007. Minerals in honey: environment, geographical and botanical aspects. Journal of Apicultural Research Bee World 46(4): 269-275.
Bogdanov, S., Jurendic, T., Sieber, R., Gallmann, P. 2008. Honey for nutrition and health: a review. J Am Coll Nutr 27(6): 677-89.
Bogdanov, S. 2009a. Honey as Nutrient and Functional Food: A Review. http://www.apitherapie.ch/files/files/Honig/8HoneyNutrientFunctionalReview. (26 November 2011).
Bogdanov, S. 2009b. Honey Composition. The Honey Book, Chapter 5. http://www.fantasticflavour.com/yahoo_site_admin/assets/docs/CompositionHoney20105942. (20 January 2012).
Bogdanov, S. 2010a. Honey in Medicine. The Honey Book. http://www.bee-hexagon.net/files/file/fileE/HealthHoney/9HoneyMedicineReview. (20 October 2011).
Bogdanov, S. 2010b. Elaboration and harvest of honey. The Honey Book, Chapter 8. http://www.bee-hexagon.net/files/file/fileE/Honey/2HoneyElaboration. (12 February 2012).
Codex Alimentarius Commission. 2001. Revised Codex standard for honey. http://www.bee-hexagon.net/files/file/fileE/ IHCPapers/Codex2001. [12 December 2011].
Cotte, J.F., Casabianca, H., Chardon, S., Lheritier, J., Grenier-Loustalot, M.F. 2004. Chromatographic analysis of sugars applied to the characterisation of monofloral honey. Anal Bioanal Chem 380(4): 698-705.
Crane, E. 1975. History of honey. In Crane E (ed.): Honey, a comprehensive survey. William Heinemann, London; 439-488.
Cuevas-Glory, L.F., Pino, J.A., Santiago, L.S., Sauri-Duch, E. 2007. A review of volatile analytical methods for determining the botanical origin of honey. Food Chemistry 103: 1032-1043.
Erejuwa, O.O., Sulaiman, S.A., Wahab, M.S., Sirajudeen, K.N., Salleh, M.S., Gurtu, S. 2010. Antioxidant protection of Malaysian Tualang honey in pancreas of normal and streptozotocin-induced diabetic rats. Ann Endocrinol (Paris) 71(4): 291-6.
Erejuwa, O.O., Sulaiman, S.A., Wahab, M.S.A., Sirajudeen, K.N.S., Salleh, S., Gurtu, S. 2012. Honey supplementation in spontaneously hypertensive rats elicits antihypertensive effect via amelioration of renal oxidative stress. Oxid Med Cell Longev ID374037
English, H.K., Pack, A.R., Molan, P.C. 2004. The effects of Manuka honey on plaque and gingivitis: a polit study. J Int Acad Periodontol 6(2): 63-7.
Fauzi, A.N., Norazmi, M.N., Yaacob, N.S. 2011. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem Toxicol 49(4): 871-8.
Ferreira I. C. F. R., Aires E., Barreira J. C. M., Estevinho L. M. 2009. Antioxidant activity of Portuguese honey sample: Different contributions of the entire honey and phenolics extract. Food Chem 114(4): 1438-1443
Finola, M.S., Lasagno, M.C., Marioli, J.M. 2007. Microbiological and chemical characterization of honeys from central Argentina. Food Chem 100: 1649-1653.
Gharzouli, K., Amira, S., Gharzouli, A., Khennouf, S. 2002. Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirininduced lesions in the rat. Exp Toxicol Pathol 54(3): 217-221.
Ghashm, A.A., Othman, N.H., Khattak, M.N., Ismail, N.N., Saini, R. 2010. Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. BMC Complement Altern Med 10: 49.
Goldstein, S.L., Leung, J.C., Silverstein, D.M. 2006. Pro- and anti-Inflammatory cytokines in chronic pediatric dialysis patients: effect of aspirin. Clin J Am Soc Nephrol 1(5): 979-986.
Hamouda, H.M., Abouwarda, A. 2011. Antimicrobial activity of bacterial isolates from honey. International Journal of Microbiological Research 2(1): 82-85.
Hanada, T., Yoshimura, A. 2002. Regulation of cytokine signaling and inflammation. Cytokine Growth Factor Rev 13(4-5): 413-421.
Tran, M.H., Nguyen, H.D., Kim, J.C., Choi, J.S., Lee, H.K., Min, B.S. 2009. Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production. Bioorg Med Chem Lett 19(15): 4389-4393.
Hussein, S.Z., Mohd Yusoff, K.M., Makpol, S., Mohd Yusof, Y.A. 2012. Gelam honey inhibits the production of proinflammatory, mediators NO, PGE2, TNF-α, and IL-6 in carrageenan-induced acute paw edema in rats. Evid Based Complement Alternat Med ID109636.
Iglesias, M.T., De Lorenzo, C., Del Carmen Polo, M., Martin-Alvarez, P.J., Pueyo, E. 2004. Usefulness of amino acids composition to discriminate between honeydew and floral honeys. Application to honeys from a small geographic area. J Agric Food Chem 52(1): 84-89.
International Honey Commission, 2002. Harmonized methods of the international honey commission. Liebefeld, Switzerland: Swiss Bee Research Centre.
Iurlina, M.O., Fritz, R. 2005. Characterization of microorganisms in Argentinean honeys from different sources. Int J Food Microbiol 105(3): 297-304.
Jaganathan, S.K., Mandal, M. 2009a. Antiproliferative effects of honey and of its polyphenols: A review. J Biomed Biotechnol ID830616.
Jaganathan, S.K., Mandal, M. 2009b. Honey constituents and their apoptotic effect in colon cancer cells. Journal of ApiProduct and ApiMedical Science 1: 29-36.
Joshi, S.R. 2008. Honey in Nepal: Approach, Strategy and Intervention for subsector Promotion.GTZ/PSP-RUFIN.www.bee-hexagon.net/files/file/fileE/Honey/HoneyinNepal. [27 October 2012].
Kassim, M., Achoui, M., Mustafa, M.R., Mohd, M.A., Yusoff, K.M. 2010a. Ellagic acid, phenolic acids and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nutr Res 30(9): 650-659.
Kassim, M., Achoui, M., Mansor, M., Yusoff, K.M. 2010b. The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues. Fitoterapia 81(8): 1196-1201.
Kenjeric, D., Mandic, M.L., Primorac, L., Bubalo, D., Perl, A. 2007. Flavonoid profile of Robinia honeys produced In Croatia. Food Chem 102: 683-690.
Khalil, M.I., Sulaiman, S.A., Gan, S.H. 2010. High 5-hydroxymethylfurfural concentrations are found in Malaysian honey samples stored for more than one year. Food Chem Toxicol 48(8-9): 2388-2392.
Khalil, M.I., Sulaiman, S.A. 2010. The potential role of honey and its polyphenols in preventing heart diseases: a review. Afr J Tradit Complement Altern Med 7(4): 315-321.
Khalil, M.I., Mahaneem, M., Jamalullail, S.M.S., Alam, N., Sulaiman, S.A. 2011. Evaluation of radical scavenging activity and colour intensity of nine Malaysian honeys of different origin. Journal of ApiProduct and ApiMedical Science 3(1): 4-11.
Khalil, M.I., Moniruzzaman, M., Boukraa, L., Benhanifia, M., Islam, A., Islam, N., Sulaiman, S.A., Gan, S.H. 2012. Physicochemical and Antioxidant Properties of Algerian Honey. Molecules 17(9): 11199-11215.
Khoo, Y.T., Halim, A.S., Singh, K.K., Mohamad, N.A. 2010. Wound contraction effects and antibacterial properties of Tualang honey on full-thickness burn wounds in rats in comparison to hydrofibre. BMC Complement altern Med 10: 48.
Kim, K.M., Kwon, Y.G., Chung, H.T., Yun, Y.G., Pae, H.O., Han, J.A., Ha, K.S., Kim, T.W., Kim, Y.M. 2003. Methanol extract of Cordyceps pruinosa inhibits in vitro and in vivo inflammatory mediators by suppressing NFκB activation. Toxicol Appl Pharmacol 190(1): 1-8.
Kingsley, A. 2001. The use of honey in the treatment of infected wound. Br J Nurs 10(22Suppl): S13-S6, S18, S20.
Koc, A.N., Silica, S., Ercal, B.D., Kasap, F., Hormet-oz, H.T., Mavus-Buldu, H. 2009. Antifungal activity of Turkish honey against Candida spp. and Trichosporon spp: an in vitro evaluation. Med Mycol 47(7): 707-12.
Lachman, J., Orsak, M., Hejtmankova, A., Kovarova, E. 2010. Evaluation of antioxidant and total phenolics of selected Czech honeys. LWT-Food Science and Technology 43: 52-58.
Lawal, R.A., Lawal, A.K., Adekalu, J.B. 2009. Physico-chemical studies on adulteration of honey in Nigeria. Pak J Biol Sci 12(15): 1080-1084.
Mahaneem, M., Siti Amrah, S., Yatiban, M.K., Hasnan, J. 2007. Effect of Malaysian honey on the male reproductive system in rats. The Malaysia Journal of Medical Sciences 14: 114.
Mahaneem, M., Sulaiman, S.A., Jaafar, H., Sirajudeen, K.N.S., Ismail, Z.I.M., Islam, M.N. 2011. Effect of honey on testicular functions in rats exposed to cigarette smoke. Journal of ApiProduct and ApiMedical Science 3(1): 12-17.
Manley, W.T. 1985. USDA (United States Department of agriculture). United States Standards for Grades of Extracted Honey. Agricultural Marketing Service. Washington DC, USA. http://www.ams.usda.gov/AMSv1.0/getfile. (9 September 2012).
Manyi-Loh, C.E., Clarke, A.M., Mkwetshana, N.F., Ndip, R.N. 2010. Treatment of Helicobacter pylori infections: Mitigating factors and prospective natural remedies. African Journal of Biotechnology 9: 2032-2042.
Mato, I., Huidobro, J.F., Simal-Lozano, J., Sancho, M.T. 2003. Significance of nonaromatic organic acids in honey. J Food Prot 66(12): 2371-2376.
Mobarok Ali, A.T., Al-Swayeh, O.A. 1997. Natural honey prevents ethanol-induced increased vascular permeability changes in the rat stomach. J Ethnopharmacol 55(3): 231-238.
Mohamed, M., Sulaiman, S.A., Sirajudeen, K.N. 2012. Protective effect of honey against cigarette smoke induced-impaired sexual behavior and fertility of male rats. Toxicol Ind Health 29(3): 264-271.
Molan, P.C. 1999. The role of honey in the management of wounds. J Wound Care 8(8): 415-418.
Molan, P.C. 2000. Establishing honey as a recognized medicine. Journal of American Apitherapy Society 7(1): 7-9.
Molan, P.C. 2001a. Why honey is effective as a medicine- 2. The scientific explanation of its effects. Bee World 82(1): 22-40.
Molan, P.C. 2001b. Honey for oral health. Journal of Dental Research 80: 1-130.
Molan, P.C. 2002. Re-introducing honey in the management of wounds and ulcers-theory and practice. Ostomy Wound Manage 48(11): 28-40.
Molan, P.C. 2006. The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 5(1): 40-54.
Mueller, M., Hobiger, S., Jungbauer, A. 2010. Anti-inflammatory activity of extracts from fruits, herbs and spices. Food Chem 122(4): 987-996.
Nasir, N.A., Halim, A.S., Singh, K.K., Dorai, A.A., Haneef, M.N. 2010. Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study. BMC Complement Altern Med 10: 31.
Ndip, R.N., Malange Takang, A.E., Echakachi, C.M., Malongue, A., Akoachere, J.F., Ndip, L.M., Luma, H.N. 2007. In vitro antimicrobial activity of selected honeys on clinical isolates of Helicobacter pylori. Afr Health Sci 7(4): 228-232.
Old Testament, The Holy Bible, proverbs. 24:13. http://www.lds.org/scriptures/ot/prov/24. (19 August 2012).
Owayele, B.V., Adenekan, O.T., Soladoye, A.O. 2011. Effects of honey on inflammation and nitric oxide production in wistar rats. Zhong Xi Yi Jie He Xue Bao 9(4): 447-452.
Perez, R.A., Sanchez-Brunette, C., Calvo, R.M., Tadeo, J.L. 2002. Analysis of volatiles from Spanish honeys by solid phase microextraction and gas chromatography mass spectrometry. J Agric Food Chem 50(9): 2633-2637.
Perez, R.A., Iglesias, M.T., Pueyo, E., Gonzalez, M., de Lorenzo, C. 2007. Amino acid composition and antioxidant capacity of Spanish honeys. J Agric Food Chem 55(2): 360-365.
Persano-Oddo, L. & Piro, R. 2004. Main European unifloral honeys: descriptive sheets. Apidologie 35: 38-81.
Piljac-Zegarac, J., Stipcevic, T., Belscak, A. 2009. Antioxidant properties and phenolic content of different floral origin honeys. J ApiProduct ApiMedical Sci 1: 43-50.
Prakash, A. Medhi, B., Avti, P.K., Saikia, U.N., Pandhi, P., Khanduja, K.L. 2008. Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats. Phytother Res 22(11): 1511-1519.
Russo, A., Cardile, V., Sanchez, F., Troncoso, N., Vanella, A., Garbarino, J.A. 2004. Chilean propolis: antioxidant activity and antiproliferative action in human tumor cell lines. Life Sci 76(5): 545-558.
Sahih Bukhari. Book 71 (7): 584, 585, 588 and 603. http://www.ikfm.se/ig/albukhari/071_sbt.html. (19 August 2012).
Sato, T., Miyata, G. 2000. The nutraceutical benefit, part 111: honey. Nutrition 16(6): 468-9.
Sela, M.O., Shapira, L., Grizim, I., Lewinstein, I., Steinberg, D., Gedalia, I., Grobler, S.R. 1998. Effects of honey consumption on enamel microhardness in normal versus xerostomic patients. J Oral Rehabil 25(8): 630-634.
Semkiw, P., Skowronek, W., Skubida, P., Rybak-Chmielewska, H., Szczesna, T. 2010. Changes occurring in honey during ripening under controlled conditions based on α-amylase activity, acidity and 5-hydroxymethylfurfural content. J Apic Sci 54(1): 55-64.
Sherif, M., Mohran, Z., Fathy, H., Rockabrand, D.M., Rozmajzl, P.J., Frenck, R.W. 2004. Universalhigh-level primary metronidazole resistance in Helicobacter pylori isolated from children in Egypt. J Clin Microbiol 42(10): 4832-4834.
Simon, A., Traynor, K., Santos, K., Blaser, G., Bode, U., Molan, P. 2009. Medical honey for wound care--still the ‘latest resort’?. Evid Based Complement Alternat Med 6(2): 165-173.
Steinberg, D., Kaine, G., Gedalia, I. 1996. Antibacterial effect of propolis and honey on oral bacteria. Am J Dent 9(6): 236-239.
Stocker, A., Schramel, P., Kettrup, A., Bengsch, E. 2005. Trace and mineral elements in royal jelly and homeostatic effects. J Trace Elem Med Biol 19(2-3): 183-189.
Swellam, T., Miyanaga, N., Onozawa, M., Hattori, K., Kawai, K., Shimazui, T., Akaza, H. 2003. Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. Int J Urol 10(4): 213-219.
Temaru, E., Simura, S., Amano, K., Karasawa, T. 2007. Antibacterial Activity of Honey from Stingless Honeybees (Hymenoptera; Apidae; Meliponinae). Pol J Microbiol 56(4): 281-285.
The National Honey Board. 2010. Honey: A reference guide to Nature’s sweetener. http://www.honey.com/images/downloads/refguide. (8 April 2011).
Tiwari, S.K., Khan, A.A., Ahmed, K.S., Ahmed, I., Kauser, F., Hussain, M.A., Ali, S.M., Alvi, A., Habeeb, A., Abid, Z., Ahmed, N., Habibullah, C.M. 2005. Rapid diagnosis of Helicobacter pylori infection in dyspeptic patients using salivary secretion: a non-invasive approach. Singapore Med J 46(5): 224-228.
Tomas-Barberan, F.A., Martos, I., Ferreres, F., Radovic, B.S., Anklam, E. 2001. HPLC flavonoid profiles as markers for the botanical origin of European unifloral honeys. J Sci Food Agric 81: 485-496.
Visavadia, B.G., Honeysett, J., Danford, M. H. 2008. Manuka honey dressing: An effective treatment for chronic wound infections. Br J Oral Maxillofac Surg 46(1): 55-56.
Wen, C.T., Hussein, S.Z., Abdullah, S., Abdul Karim, N., Makpol, S., Mohd Yusof, Y.A. 2012. Gelam and Nenas honeys inhibit proliferation of HT 29 colon cancer cells by inducing DNA damage and apoptosis while suppressing inflammation. Asian Pac J Cancer Prev 13(4): 1605-1610.
Weston, R. 2000. The contribution of catalase and other natural products to the antibacterial activity of honey: a review. Food Chem 71(2): 235-239.
Yaghoobi, N., Al-Waili, N., Ghayour-Mobarhan, M., Parizadeh, S.M., Abasalti, Z., Yaghoobi, Z., Yaghiibi, F., Esmaeli, H., Kazemi-Bajestani, S.M., Aghasizadeh, R., Saloom, K.Y., Ferns, G.A. 2008. Natural honey and cardiovascular risk factors; Effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose. Scientific World Journal 8: 463-469.
Yaoa, L., Jiang, Y., Singanusong, R., Datta, N., Raymont, K. 2005. Phenolic acids in Australian Melaleuca, Guioa, Laphostemon, Banksia and Helianthus honeys and their potential for floral authentication. Food Research International. 38: 651-658.
Yusof, N., Ainul Hafiza, A.H., Zohdi, R.M., Bakar, M.Z.A. 2007. Development of honey hydrogel dressing for enhanced wound healing. Radiation Physics and Chemistry 76(11-12): 1767-1770.
Zaharil, M.S.A., Wan Sulaiman, W.A., Halim, A.S., Shah Jumaat, M.Y. & Hasnan, J. 2011. The Efficacy of Tualang Honey in comparison to silver in dressing wounds in rats. Journal of ApiProduct and ApiMedical Science 3(1): 45-53.
Zaid, S.S., Sulaiman, S.A., Sirajudeen, K.N., Othman, N.H. 2010. The effects of tualang honey on female reproductive organs, tibia bone and hormonal profile in ovariectomised rats - animal model for menopause. BMC Complement Alternt Med 10: 82.
Zappala, M., Fallico, B., Arena, E., Verzera, A. 2005. Methods for the determination of HMF in honey: a comparison. Food Control 16: 273-277.
Zeina, B., Othman, O., Al-Assad, S. 1996. Effect of honey versus thyme on Rubella virus survival in vitro. J Altern Complement Med 2(3): 345-8.
Zeina, B., Zohra, B.I., Al-Assad, S. 1997. The effects of honey on Leishmania parasites: an in vitro study. Trop Doct 27(Supp 1): 36-38.
Zhou, Q., Wintersteen, C.L., Cadwallader, R.W. 2002. Identification and quantification of aroma-active compounds that contribute to the distinct malty flavor of buckwheat honey. J Agric Food Chem 50(7): 2016-2021.
Zohdi, R.M., Zakaria, Z.A.B., Mustapha, N.M., Yusof, N., & Abdullah, M.N.H. 2004. The effect of topical application of Malaysian honey on burn wound healing. Jurnal Veterinar Malaysia 16(1-2): 47-50.
Zohdi, R.M, Zakaria, Z.A.B., Yusof, N., Mustapha, N.M., Abdullah, M.N.H. 2012. Gelam (Melaleuca spp.) honey-based hydrogel as burn wound dressing. Evid Based Complement Alternat Med ID843025.
