Squamous Cell Carcinoma of the Tongue in A Patient with Rothmund-Thomson Syndrome (Recq4 Mutation) - Intolerance to Radiotherapy
Intolerance to radiotherapy in squamous cell carcinoma of the tongue
Vol. 4 No. 2 : 2009 (133-137)
Abstract
We report a case of squamous cell carcinoma of the base of the tongue in a 27 years old patient with Rothmund-Thomson syndrome (RTS). An abnormal DNA repair mechanism in some RTS patients predispose them to malignancy and influence the tolerance to radiotherapy.
Keywords :
radiation toxicity,
Rothmund-Thomson syndrome,
squamous cell carcinoma tongue,
Correspondance Address
Assoc Prof Dr Hamidah Alias, Department of Pediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur. Tel: 603-91455396. Fax: 603-91737827. Email: midalias@ppukm.ukm.my
