A Tale of Two Boys: Case Report on Non-Consanguineous Siblings with Cerebral Palsy
Familial Cerebral Palsy
Vol. 9 No. 1 : 2014 (74-79)
Abstract
Cerebral palsy is a common cause of childhood disability. It has a great impact on parents and caregivers, especially when it reoccurs in the same family. Although familial cerebral palsy is relatively uncommon, cases have been reported among children from consanguineous, non-consanguineous marriages and multiple pregnancies suggesting a possible complex genetic mode of inheritance. Physicians need to be aware of the possibility of familial cerebral palsy for early detection and counseling. We describe a rare case of two male siblings from a non-consanguineous marriage affected by cerebral palsy.
Keywords :
cerebral palsy,
familial,
palsy,
recurrent,
siblings,
Correspondance Address
Assoc. Prof. Dr Leelavathi Muthupalaniappen, Department of Family Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: 603 91456123 Fax: 603 9145 6688 Email: drleelaraj@gmail.com
References
Adler, E.1961. Familial cerebral palsy. J Chronic Dis 13: 207-14.
Djukic, M., Gibson, C.S., Maclennan, A.H., Goldwater, P.N., Haan, E.A., McMichael, G., Priest, K., Dekker ,G.A., Hague, W.M., Chan, A., Rudzki, Z., VAN Essen, P., Khong, T.Y., Morton, M.R., Ranieri, E., Scott, H., Tapp, H., Casey, G. 2009. Genetic susceptibility to viral exposure may increase the risk of cerebral palsy. Aust N Z J Obstet Gynaecol 49(3): 247-53.
Gibson, C.S., MacLennan, A.H., Dekker, G.A., Goldwater, P.N., Sullivan, T.R., Munroe, D.J., Tsang, S., Stewart, C, Nelson, K.B. 2008. Candidate genes and cerebral palsy: a population-based study. Pediatrics 122(5): 1079–85.
Hemminki, K., Li, X., Sundquist, K., Sundquist, J. 2007.High familial risks for cerebral palsy implicate partial heritable aetiology. Paediatr Perinat Epidemiol 21(3): 235-41.
McHale, D.P., Jackson, A.P, Campbell., Levene, M.I., Corry, P., Woods, C.G., Lench, N.J., Mueller, R.F., Markham, A.F. 2000. A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. Eur J Hum Genet 8(4): 267-72.
Mukherjee. A., Varma, S.K., Kucheria, K., Bole, S.V.1973. Familial cerebral palsy. J Indian Med Assoc 60(8): 300-1.
National Institute of Neurological Disorders and Stroke. 2013. Cerebral Palsy: Hope Through Research.www.ninds.nih.gov/disorders/cerebral_palsy/detail_cerebral_palsy.htm. [1 Mei 2013].
Pharoah, P.O. 2005. Risk of cerebral palsy in multiple pregnancies. Obstet Gynecol Clin North Am 32(1): 55-67.
Rajab, A., Yoo, S.Y., Abdulgalil, A., Kathiri, S., Ahmed, R., Mochida, G.H., Bodell, A., Barkovich, A.J., Walsh, C.A. 2006. An autosomal recessive form of spastic cerebral palsy (CP) with microcephaly and mental retardation. Am J Med Genet A 140(14): 1504-10.
Reddihough, D.S., Collins, K.J. 2003. The epidemiology and causes of cerebral palsy. Aust J Physiother 49(1): 7-14.
Richer, L.P., Dower, N.A., Leonard, N., Chan, A.K., Robertson, C.M. 2011. Familial recurrence of cerebral palsy with multiple risk factors. Case Rep Pediatr 2011: 307857.
Rosenbaum, P., Paneth, N., Leviton, A., Goldstein, M., Bax, M., Damiano, D., Dan, B., Jacobsson, B. 2007. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl 109: 8-14.
Tollånes, M.C., Wilcox, A.J., Lie, R.T., Moster, D. 2014. Familial risk of cerebral palsy: population based cohort study. BMJ 349: g4294
