The Rare Primary Low Grade Papillary Adenocarcinoma of Nasopharynx: A Diagnostic Challenge and Management
Primary Low Grade Papillary Adenocarcinoma of Nasopharynx
Vol. 10 No. 2 : 2015 (137-140)
Abstract
Low Grade Papillary Nasopharyngeal Adenocarcinoma (LGPAC) is a very rare tumour of mucosal origin compared to a higher incidence of well differentiated keratinized/non-keratinized nasopharyngeal carcinoma. It is an epithelial tumour with glandular differentiation. Its papillary figure seen histologically, is also seen in metastatic papillary thyroid carcinoma. This has caused a significant challenge to the Pathologist to differentiate primary papillary nasopharyngeal adenocarcinoma and metastatic tumour. Thyroid Transcription Factor-1 (TTF-1) is also expressed in subsets of papillary nasopharyngeal adenocarcinoma, which is valuable as a diagnostic tool. LGPAC is a benign-like malignant neoplasm. An early diagnosis with a complete tumour removal via conventional excision or endoscopic approach has offered a good prognosis with low risk of recurrence.
Keywords :
Adenocarcinoma Papillary,
Nasopharynx,
thyroid neoplasms,
Correspondance Address
Noor Dina Hashim, Department of Otorhinolaryngology-Head & Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia. Tel: +60391456046 Fax: +60391456675 Email: dinahashim81@yahoo.com
References
Fu, C.H., Chang, K.P., Ueng, S.H., Wu, C.C., Hao, S.P. 2008. Primary thyroid-like papillary adenocarcinoma of the nasopharynx. Auris Nasus Larynx 35(4): 579-82.
Ohe, C., Sakaida, N., Tadokoro, C., Fukui, H., Asako, M., Tomoda, K., Uemure, Y. 2010. Thyroid-like low grade nasopharyngeal papillary adenocarcinoma: report of two cases. Pathol Int 60(2): 107-11.
Pineda-Daboin, K., Neto, A., Ochoa-Perez, V., Luna, M.A. 2006. Nasopharyngeal adenocarcinomas: a clinicopathologic study of 44 cases including immunohistochemical features of 18 papillary phenotypes. Ann Diagn Pathol 10(4): 215-21.
Wu, P.Y., Huang, C.C., Chen, H.K., Chien, C.Y. 2007. Adult thyroid-like low-grade nasopharyngeal papillary adenocarcinoma with thyroid transcription factor-1 expression. Otolaryngol Head Neck Surg 137(5): 837-8.
